Photostable aqueous solution comprising benzyl alcohol derivatives

ABSTRACT

Aqueous solution, including at least one of optically active (-)-(R)-α-((tert-butylamino)methyl)-2-chloro-4-hydroxybenzyl alcohol represented by the following formula: ##STR1## and pharmacologically acceptable salt thereof. The aqueous solution also includes at least one photostabilizer selected from the group consisting of saccharide, sugar alcohol, and polyalcohol. A content of the at least one of optically active (-)-(R)-α-((tert-butylamino)methyl)-2-chloro-4-hydroxybenzyl alcohol and pharmacologically acceptable salt thereof is 0.01 to 10% (w/v) based on a volume of the aqueous solution. A content of the at least one photostabilizer is 1 to 50% (w/v) based on the volume of the aqueous solution. The content of the at least one photostabilizer is at least 10% (w/w) based on a total weight of the at least one of optically active (-)-(R)-α-((tert-butylamino)methyl)-2-chloro-4-hydroxybenzyl alcohol and pharmacologically acceptable salt thereof. Method of making a stabilized aqueous solution.

CROSS-REFERENCE TO RELATED APPLICATIONS

This application is a continuation of application Ser. No. 08/983,329, filed Jul. 12, 1996, which is the U.S. National Stage of International Application No. PCT/JP96/01950, Jul. 12, 1996, and claim priority of Japanese Application No. 7-219729, filed Aug. 4, 1995. The entire disclosure of application Ser. No. 08/983,329 is considered as being part of the disclosure of this application, and the entire disclosure of application Ser. No. 08/983,329 is expressly incorporated by reference herein in its entirety.

BACKGROUND OF THE INVENTION

1. Technical Field

The present invention relates to a pharmaceutical composition in the form of an aqueous solution with improved photostability which comprises as an active ingredient a benzyl alcohol compound having excellent stimulating activity on an adrenergic β₂ -receptor and useful as a uterine relaxing agent, bladder relaxing agent and the like.

2. Background Art

Optically active (-)-(R)-α-[(tert-butylamino)methyl]-2-chloro-4-hydroxybenzyl alcohol (hereinafter referred to as "the present compound") represented by the following formula (I): ##STR2## and pharmacologically acceptable salts thereof, which have uterine relaxing activity, bladder relaxing activity and other, have been revealed useful as a therapeutic medicament for threatened premature delivery or a therapeutic medicament for urination disorders such as urinary incontinence, nocturnal enuresis or the like (Japanese Patent Unexamined Publication No. (Hei) 178356/1992).

SUMMARY OF THE INVENTION

For emergent therapy of threatened premature delivery, it is desirable to use an injection by which rapid manifestation of efficacy can be expected. For therapeutic treatment of urination disorder such as urinary incontinence, nocturnal enuresis or the like, which are frequent in the elderly or children, orally applicable liquid formulations are clinically very useful in view of lowered deglutition ability of the elderly and convenient administration to children.

The inventors of the present invention conducted various studies to provide a pharmaceutical composition in the form of an aqueous solution comprising the present compound as an active ingredient. In the course of the studies, they found that the present compound was unstable in an aqueous solution and easily formed decomposed products under irradiation with light, and that an amount of the photodecomposition products tended to be further increased by the addition of a buffering agent required to maintain pH of the solution, e,g., citric acid, acetic acid, L-tartaric acid, D-tartaric acid, or DL-tartaric acid. These findings have not yet been reported so far.

Generally, brown containers for protection from light are used to distribute an aqueous solution for a use as a pharmaceutical composition which contains a photounstable drug as an active ingredient. It was found that the photodecomposition of the present compound was partly prevented by filling an aqueous solution comprising the present compound as an active ingredient in brown containers. However, the results were far from satisfactory from a viewpoint of stability essential to pharmaceutical formulations. The results can be elucidated that light with a relatively short wavelength, i.e., 400 nm or less, is primarily involved in photodecomposition of an ordinary organic compound, and for this reason, brown containers are designed to mainly achieve protection from light having a short wavelength of 400 nm or less, whereas light having a longer wavelength above 400 nm is also involved in the photodecomposition of the present compound, and accordingly, sufficient protection from light cannot be achieved by the brown containers. Therefore, in order to distribute a stable aqueous solution for a use as a pharmaceutical composition which comprises the present compound as an active ingredient, it is necessary to develop a means to achieve higher photostability.

An object of the present invention is to provide a pharmaceutical composition in the form of an aqueous solution having improved photostability which comprises the present compound or a pharmacologically acceptable salt thereof as an active ingredient. In particular, the object of the present invention is to provide a pharmaceutical composition having satisfactory photostability against light of long wavelength which cannot be sufficiently reduced even by using a brown container.

Another object of the present invention is to provide a highly safe photostabilizer which suppresses the photodecomposition of the present compound or a pharmacologically acceptable salt thereof, and can be formulated in a pharmaceutical composition.

The inventors of the present invention made eager efforts to achieve the foregoing objects, and as a result, they found that the photodecomposition of the present compound was remarkably suppressed by the addition of a substance selected from saccharides, sugar alcohols, and polyalcohols to an aqueous solution containing the present compound, and that the photodecomposition of the present compound caused by the light transmitted by a brown container was completely prevented. The present invention was achieved on the basis of these findings. Saccharides, sugar alcohols, and polyalcohols are used as isotonicities or excipients in formulations as pharmaceutical compositions. However, their photostabilizing functions for the present compound has not yet been known.

The present invention thus provides an aqueous solution characterized in that said solution comprises optically active (-)-(R)-α-[(tert-butylamino)methyl]-2-chloro-4-hydroxybenzyl alcohol represented by the following formula (I): ##STR3## or a pharmacologically acceptable salt thereof, together with at least one photostabilizer selected from the group consisting of saccharides, sugar alcohols, and polyalcohols.

According to preferred embodiments of the present invention, there are provided the aforementioned solution wherein the saccharide is selected from the group consisting of glucose, sucrose, fructose, and maltose; the aforementioned solution wherein the sugar alcohol is selected from the group consisting of xylitol, sorbitol, and mannitol; the aforementioned solution wherein the polyalcohol is selected from the group consisting of glycerin and propylene glycol; the aforementioned solution wherein a pH is 6.5 or less; the aforementioned solution wherein a content of the optically active (-)-(R)-α-[(tert-butylamino)methyl]-2-chloro-4-hydroxybenzyl alcohol or a pharmacologically acceptable salt thereof is 0.01-10% (w/v) based on a volume of the aqueous solution; the aforementioned solution wherein a content of the photostabilizer selected from the group consisting of saccharides, sugar alcohols, and polyalcohols is 1-50% (w/v) based on a volume of the aqueous solution; and the aforementioned solution which contains 10% (w/w) or more of the photostabilizer based on the total weight of the optical active (-)-(R)-α-[(tert-butylamino)methyl]-2-chloro-4-hydroxybenzyl alcohol or a pharmacologically acceptable salt thereof.

According to another aspect of the present invention, there is provided a photostabilizer selected from the group consisting of saccharides, sugar alcohols, and polyalcohols which suppresses the photodecomposition of the optically active (-)-(R)-α-[(tert-butylamino)methyl]-2-chloro-4-hydroxybenzyl alcohol or a pharmacologically acceptable salt thereof contained in an aqueous solution; and a photostabilized aqueous solutions comprising the optically active (-)-(R)-α-[(tert-butylamino)methyl]-2-chloro-4-hydroxybenzyl alcohol or a pharmacologically acceptable salt thereof together with a substance selected from the group consisting of saccharides, sugar alcohols and polyalcohols.

According to further aspect of the present invention, there is provided a therapeutic medicament for threatened premature delivery or urination disorders which comprises the aforementioned photostabilized solution.

DETAILED DESCRIPTION

The aqueous solution of the present invention is a pharmaceutical composition which can be used as a medicament for oral administration or parenteral administration such as by intravenous injection. The solution is characterized to contain the optically active (-)-(R)-α-[(tert-butylamino)methyl]-2-chloro-4-hydroxybenzyl alcohol or a pharmacologically acceptable salt thereof, together with a substance selected from the group consisting of saccharides, sugar alcohols, and polyalcohols as a photostabilizer for said compound.

The present compound represented by formula (I) can be prepared by, for example, the method described in the Japanese Patent Unexamined Publication No. (Hei) 178356/1992. The pharmacologically acceptable salts of the present compound include, for example, mineral acid salts such as hydrochloride, hydrobromide, hydriodide, nitrate, sulfate, or phosphate, and organic acid salts such as acetate, maleate, fumarate, citrate, oxalate, malate, methanesulfonate, p-toluenesulfonate, mandelate, D-10-camphorsulfonate, L-10-camphorsulfonate, DL-10-camphorsulfonate, L-tartrate, D-tartrate, DL-tartrate, succinate and the like.

A content of the present compound or a pharmacologically acceptable salt thereof in the aqueous solution of the present invention may be 0.01-10% (w/v), preferably 0.02-5% (w/v), and more preferably 0.05-0.5% (w/v) based on the total volume of the solution. The aqueous solution of the present invention may contain one or more of the active ingredients selected from the present compound and pharmacologically acceptable salts thereof.

The photostabilizer has a function to reduce or prevent the photodecomposition of the present compound or a pharmacologically acceptable salt thereof in an aqueous solution. Examples of the saccharides include, for example, glucose, sucrose, fructose, maltose and the like; examples of the sugar alcohols include, for example, xylitol, sorbitol, mannitol and the like; and examples of the polyalcohols include, for example, glycerin, propylene glycol and the like. The aqueous solution of the present invention may contain one or more of these photostabilizers.

The type and amount of the photostabilizer used according to the present invention may be appropriately chosen so as to achieve a desired photostability depending on the type of the active ingredient selected from the present compound or pharmacologically acceptable salts thereof. As a test for the photostability, the method described in Examples of the specification may be employed. For example, 1-50% (w/v), preferably 2-10% (w/v) of the photostabilizer based on the total volume of the aqueous solution may be formulated. The photostabilizer may also be formulated in an amount of 10% (w/w) or more based on a weight of the present compound or a pharmacologically acceptable salt thereof as an active ingredient.

The pH of the aqueous solution of the present invention may preferably be adjusted to 6.5 or lower, most preferably 3-6.5. Acids or bases used for adjusting the pH are not particularly limited so long as they can be added in pharmaceuticals. For example, hydrochloric acid, sodium hydroxide or other may be used. If necessary, a buffering agent such as citric acid, acetic acid, L-tartaric acid, D-tartaric acid, or DL-tartaric acid may be added. Amounts of the buffering agent are not particularly limited, however, it is preferable to add a minimum amount of the buffering agent that is capable of adjusting or maintaining a desired pH. The aqueous solutions of the present invention has a characteristic feature in that the solution is free from photodecomposition of the present compound or a pharmacologically acceptable salt thereof even when the solution is added with a buffering agent such as citric acid, acetic acid, L-tartaric acid, D-tartaric acid, or DL-tartaric acid.

When the aqueous solution of the present invention is used as an injection, the addition of an isotonizer is preferred. However, partial or complete isotonization is sometimes achieved by the photostabilizer contained in the aqueous solution of the present invention, and in that case, it is generally unnecessary to use an entire amount of theoretically-required isotonizer. For example, when glucose or mannitol is used as the photostabilizer in an amount of about 5% (w/v) based on the total volume of the aqueous solution, or when propylene glycol is used in an amount of about 2% (w/v), the aqueous solution is sufficiently isotonized, and therefore, it is generally unnecessary to add an isotonizer.

Methods for preparing the aqueous solution of the present invention are not particularly limited. For example, the solution can be prepared by dissolving, simultaneously or in an appropriate order in purified water or water for injection, respective required amounts of the present compound or a pharmacologically acceptable salt thereof as an active ingredient, the photostabilizer, and other pharmaceutical additives, e.g., a buffering agent, a pH modifier, an isotonizer, an antiseptic, and a soothing agent, if necessary, and then optionally subjecting the resulting solution to a sterilization process such as heat sterilization and sterilization with filtration. As the present compound or a pharmacologically acceptable salt thereof as an active ingredient, any type of known or unknown crystals, or any type of known or unknown hydrates may be used.

EXAMPLES

The present invention will be further detailed by referring to the following examples. However, the scope of the present invention is not limited to these specific examples.

Example 1

    ______________________________________                                         L-Tartrate of the present compound                                                                0.2 mg                                                      Propylene glycol   20 mg                                                       Citric acid        0.3 mg                                                      Sodium hydroxide   Sufficient quantity                                         Hydrochloric acid  Sufficient quantity                                         Water              Sufficient quantity                                         Total              1 ml                                                        pH                 5.0                                                         ______________________________________                                    

L-Tartrate of the present compound, propylene glycol, and citric acid were weighed in the ratio according to the aforementioned prescription, and then dissolved in water. The solution was adjusted to pH 5 with sodium hydroxide or hydrochloric acid, and then added with water up to the total volume so as to obtain the prescribed concentrations. The solution was then filled in a brown container and sealed.

Examples 2-20

According to the method of Example 1, solutions of Examples 2-20 were obtained. Prescriptions for these examples are shown in Tables 1-3.

    ______________________________________                                         Example No.                                                                             Example 1 Example 2 Example 3                                                                              Example 4                                 ______________________________________                                         L-Tartrate of                                                                           0.2 mg    1 mg      5 mg    50 mg                                     the present                                                                    compound                                                                       Photostabilizer                                                                         Propylene Propylene Propylene                                                                              Propylene                                          glycol 20 mg                                                                             glycol 20 mg                                                                             glycol 20 mg                                                                           glycol 20 mg                              Acid (citric                                                                            0.3 mg    0.3 mg    0.3 mg  0.3 mg                                    acid)                                                                          Sodium   Sufficient                                                                               Sufficient                                                                               Sufficient                                                                             Sufficient                                hydroxide                                                                               quantity  quantity  quantity                                                                               quantity                                  Hydrochloric                                                                            Sufficient                                                                               Sufficient                                                                               Sufficient                                                                             Sufficient                                acid     quantity  quantity  quantity                                                                               quantity                                  Water    Sufficient                                                                               Sufficient                                                                               Sufficient                                                                             Sufficient                                         quantity  quantity  quantity                                                                               quantity                                  Total volume                                                                            1 ml      1 ml      1 ml    1 ml                                      pH       5.0       5.0       5.0     5.0                                       Osmotic  1.0       1.0       1.1     2.2                                       pressure ratio                                                                 ______________________________________                                         Example No.                                                                             Example 5 Example 6 Example 7                                                                              Example 8                                 ______________________________________                                         L-Tartrate of                                                                           1 mg      1 mg      1 mg    1 mg                                      the present                                                                    compound                                                                       Photostabilizer                                                                         Propylene Propylene Propylene                                                                              Propylene                                          glycol    glycol    glycol  glycol                                             20 mg     20 mg     10 mg   100 mg                                    Acid (citric                                                                            0.3 mg    0.3 mg    0.3 mg  0.3 mg                                    acid)                                                                          Sodium   Sufficient                                                                               Sufficient                                                                               Sufficient                                                                             Sufficient                                hydroxide                                                                               quantity  quantity  quantity                                                                               quantity                                  Hydrochloric                                                                            Sufficient                                                                               Sufficient                                                                               Sufficient                                                                             Sufficient                                acid     quantity  quantity  quantity                                                                               quantity                                  Water    Sufficient                                                                               Sufficient                                                                               Sufficient                                                                             Sufficient                                         quantity  quantity  quantity                                                                               quantity                                  Total volume                                                                            1 ml      1 ml      1 ml    1 ml                                      pH       3.0       6.5       5.0     5.0                                       Osmotic  1.0       1.0       0.5     5.3                                       pressure ratio                                                                 ______________________________________                                         Example No.                                                                             Example 9 Example 10                                                                               Example 11                                                                             Example 12                                ______________________________________                                         L-Tartrate of                                                                           1 mg      1 mg      1 mg    1 mg                                      the present                                                                    compound                                                                       Photostabilizer                                                                         Glucose   Sucrose   Fructose                                                                               Maltose                                            47 mg     89 mg     47 mg   95 mg                                     Acid (citric                                                                            0.3 mg    0.3 mg    0.3 mg  0.3 mg                                    acid)                                                                          Sodium   Sufficient                                                                               Sufficient                                                                               Sufficient                                                                             Sufficient                                hydroxide                                                                               quantity  quantity  quantity                                                                               quantity                                  Hydrochloric                                                                            Sufficient                                                                               Sufficient                                                                               Sufficient                                                                             Sufficient                                acid     quantity  quantity  quantity                                                                               quantity                                  Water    Sufficient                                                                               Sufficient                                                                               Sufficient                                                                             Sufficient                                         quantity  quantity  quantity                                                                               quantity                                  Total volume                                                                            1 ml      1 ml      1 ml    1 ml                                      pH       5.0       5.0       5.0     5.0                                       Osmotic  1.0       1.0       1.0     1.0                                       pressure ratio                                                                 ______________________________________                                         Example No.                                                                             Example 13                                                                               Example 14                                                                               Example 15                                                                             Example 16                                ______________________________________                                         L-Tartrate of                                                                           1 mg      1 mg      1 mg    1 mg                                      the present                                                                    compound                                                                       Photostabilizer                                                                         Xylitol   Sorbitol  Mannitol                                                                               Glycerin                                           40 mg     47 mg     47 mg   25 mg                                     Acid (citric                                                                            0.3 mg    0.3 mg    0.3 mg  0.3 mg                                    acid)                                                                          Sodium   Sufficient                                                                               Sufficient                                                                               Sufficient                                                                             Sufficient                                hydroxide                                                                               quantity  quantity  quantity                                                                               quantity                                  Hydrochloric                                                                            Sufficient                                                                               Sufficient                                                                               Sufficient                                                                             Sufficient                                acid     quantity  quantity  quantity                                                                               quantity                                  Water    Sufficient                                                                               Sufficient                                                                               Sufficient                                                                             Sufficient                                         quantity  quantity  quantity                                                                               quantity                                  Total volume                                                                            1 ml      1 ml      1 ml    1 ml                                      pH       5.0       5.0       5.0     5.0                                       Osmotic  1.0       1.0       1.0     1.0                                       pressure ratio                                                                 ______________________________________                                         Example No.                                                                             Example 17                                                                               Example 18                                                                               Example 19                                                                             Example 20                                ______________________________________                                         The present                                                                             L-Tartrate                                                                               L-Tartrate        Hydro-                                    compound 1 mg      1 mg      0.6 mg  chloride                                                                       0.7 mg                                    Photostabilizer                                                                         Propylene Propylene Propylene                                                                              Propylene                                          glycol    glycol    glycol  glycol                                             20 mg     20 mg     20 mg   20 mg                                     Acid     Acetic acid                                                                              L-Tartaric                                                                               Citric acid                                                                            Citric acid                                        0.3 mg    acid 1.0 mg                                                                              0.3 mg  0.3 mg                                    Sodium   Sufficient                                                                               Sufficient                                                                               Sufficient                                                                             Sufficient                                hydroxide                                                                               quantity  quantity  quantity                                                                               quantity                                  Hydrochloric                                                                            Sufficient                                                                               Sufficient                                                                               Sufficient                                                                             Sufficient                                acid     quantity  quantity  quantity                                                                               quantity                                  Water    Sufficient                                                                               Sufficient                                                                               Sufficient                                                                             Sufficient                                         quantity  quantity  quantity                                                                               quantity                                  Total volume                                                                            1 ml      1 ml      1 ml    1 ml                                      pH       5.0       5.0       5.0     5.0                                       Osmotic  1.0       1.0       1.0     1.0                                       pressure ratio                                                                 ______________________________________                                    

Comparative Example 1

    ______________________________________                                         L-Tartrate of the present compound                                                                1 mg                                                        Citric acid        0.3 mg                                                      Sodium hydroxide   Sufficient quantity                                         Hydrochloric acid  Sufficient quantity                                         Water              Sufficient quantity                                         Total              1 ml                                                        pH                 5.0                                                         ______________________________________                                    

L-Tartrate of the present compound and citric acid were weighed in the ratio according to the aforementioned prescription, and then dissolved in water. The solution was adjusted to pH 5 with sodium hydroxide or hydrochloric acid, and then added with water up to the total volume so as to obtain the above concentrations. The solution was then filled in a brown container and sealed.

Comparative Examples 2-7

According to the method of Comparative Example 1, solutions of Comparative Examples 2-7 were obtained. Prescriptions for these comparative examples are shown in Table 4.

    ______________________________________                                         Comparative                                                                             Comparative                                                                              Comparative                                                                              Comparative                                                                            Comparative                               Example No.                                                                             Example 1 Example 2 Example 3                                                                              Example 4                                 ______________________________________                                         L-Tartrate of                                                                           1 mg      1 mg      1 mg    1 mg                                      the present                                                                    compound                                                                       Additive --        Sodium    Boric acid                                                                             Sodium                                                       chloride  19 mg   hydrogen                                                     8 mg              carbonate                                                                      13 mg                                     Acid (citric                                                                            0.3 mg    0.3 mg    0.3 mg  0.3 mg                                    acid)                                                                          Sodium   Sufficient                                                                               Sufficient                                                                               Sufficient                                                                             Sufficient                                hydroxide                                                                               quantity  quantity  quantity                                                                               quantity                                  Hydrochloric                                                                            Sufficient                                                                               Sufficient                                                                               Sufficient                                                                             Sufficient                                acid     quantity  quantity  quantity                                                                               quantity                                  Water    Sufficient                                                                               Sufficient                                                                               Sufficient                                                                             Sufficient                                         quantity  quantity  quantity                                                                               quantity                                  Total volume                                                                            1 ml      1 ml      1 ml    1 ml                                      pH       5.0       5.0       5.0     5.0                                       Osmotic  0.03      0.9       1.1     1.1                                       pressure ratio                                                                 ______________________________________                                         Comparative                                                                             Comparative                                                                              Comparative                                                                              Comparative                                       Example No.                                                                             Example 5 Example 6 Example 7                                         ______________________________________                                         L-Tartrate of                                                                           1 mg      1 mg      1 mg                                              the present                                                                    compound                                                                       Additive Sodium    Magnesium Potassium                                                  acetate   chloride  chloride                                                   20 mg     21 mg     11 mg                                             Acid (citric                                                                            0.3 mg    0.3 mg    0.3 mg                                            acid)                                                                          Sodium   Sufficient                                                                               Sufficient                                                                               Sufficient                                        hydroxide                                                                               quantity  quantity  quantity                                          Hydrochloric                                                                            Sufficient                                                                               Sufficient                                                                               Sufficient                                        acid     quantity  quantity  quantity                                          Water    Sufficient                                                                               Sufficient                                                                               Sufficient                                                 quantity  quantity  quantity                                          Total volume                                                                            1 ml      1 ml      1 ml                                              pH       5.0       5.0       5.0                                               Osmotic  1.1       1.0       1.0                                               pressure ratio                                                                 ______________________________________                                    

Test Example Photostability test

To examine photostability, each sample sealed in a brown container was stored under irradiation with a fluorescent lamp (3500 luxes, wavelength range: 300-700 nm) at 25° C. for 15 days, and then amounts of decomposed products produced were measured by HPLC. The results are shown in Table 5. From 0.08 to 0.44% of decomposed products were observed in the comparative examples, whereas no decomposition product was observed in the aqueous solutions of the present invention, which verified their excellent photostability.

    ______________________________________                                         Example No. and Decomposed amount under                                        Comparative Example                                                                            irradiation at 3500 luxes for                                  No.             15 days (%)                                                    ______________________________________                                         Examples 1-20   N.D.                                                           Comparative Example 1                                                                          0.44                                                           Comparative Example 2                                                                          0.22                                                           Comparative Example 3                                                                          0.13                                                           Comparative Example 4                                                                          0.09                                                           Comparative Example 5                                                                          0.10                                                           Comparative Example 6                                                                          0.08                                                           Comparative Example 7                                                                          0.18                                                           ______________________________________                                          N.D.: 0.05% or less                                                      

Industrial Applicability

The aqueous solution of the present invention comprising the present compound or a pharmacologically acceptable salt thereof as an active ingredient is stable to light, and has desirable stability as a pharmaceutical preparation. In addition, the photostabilizer added to the aqueous solutions of the present invention is highly safe, and the aqueous solution of the present invention has satisfactory safety as a medicament. Therefore, the aqueous solution is parenterally or orally applicable as a therapeutic medicament for uterine relaxation, bladder relaxation or other. 

What is claimed is:
 1. l An aqueous solution, comprising:at least one of optically active (-)-(R)-α-((tert-butylamino)methyl)-2-chloro-4-hydroxybenzyl alcohol represented by the following formula: ##STR4## and pharmacologically acceptable salt thereof; and at least one photostabilizer selected from the group consisting of saccharide, sugar alcohol, and polyalcohol; wherein a content of the at least one photostabilizer is at least 10% (w/w) based on a total weight of the at least one of optically active (-)-(R)-α-((tert-butylamino)methyl)-2-chloro-4-hydroxybenzyl alcohol and pharmacologically acceptable salt thereof.
 2. The aqueous solution of claim 1, wherein a content of the at least one of optically active (-)-(R)-α-((tert-butylamino)methyl)-2-chloro-4-hydroxybenzyl alcohol and pharmacologically acceptable salt thereof is 0.01 to 10% (w/v) based on a volume of the aqueous solution. 